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Small GTpases in acrosomal exocytosis
(Springer, 2015-01)
Regulated exocytosis employs a conserved molecular machinery in all secretory cells. Soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Rab superfamilies are members of this machinery. Rab ...
Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis
(Oncotarget, 2015-09-08)
Metastatic oral squamous cell carcinoma (OSCC) is frequently associated with recurrent gene abnormalities at specific chromosomal loci. Here, we utilized array comparative genomic hybridization and genome-wide screening ...
Coxiella burnetii localizes in a Rab7-labeled compartment with autophagic characteristics
(Amer Soc Microbiology, 2002-10-01)
The obligate intracellular bacterium Coxiella burnetii, the agent of Q fever in humans and of coxiellosis in other animals, survives and replicates within large, acidified, phagolysosome-like vacuoles known to fuse homo- ...
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation
(Elsevier, 2015)
The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.
(Company of Biologists, 2015-08)
Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport. These bacteria hijack Rab6-, Rab11- and Rab14-controlled ...
Spatial-temporal study of Rab1b dynamics and function at the ER-Golgi interface
(Public Library of Science, 2016-08)
The GTPase Rab1b is involved in ER to Golgi transport, with multiple Rab1b effectors (located at ERES, VTCs and the Golgi complex) being required for its function. In this study, we performed live-cell dual-expression ...