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Crystal structure and molecular dynamics studies of human purine nucleoside phosphorylase complexed with 7-deazaguanine
(Academic Press Inc Elsevier ScienceSan DiegoEUA, 2010)
Descriptor-and fragment-based QSAR models for a series of Schistosoma mansoni purine nucleoside inhibitors
(Sociedade Brasileira de Química, 2011)
The enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the treatment of major parasitic infectious diseases, with special emphasis on its role in the discovery of ...
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
(Elsevier B.V., 2004-01-23)
Human purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent ...
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
(Elsevier B.V., 2004-01-23)
Human purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent ...
New catalytic mechanism for human purine nucleoside phosphorylase
(Elsevier B.V., 2005-02-18)
Human purine nucleoside phosphorylase has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of human PNP. Recently, several structures of human PNP have been ...
New catalytic mechanism for human purine nucleoside phosphorylase
(Elsevier B.V., 2005-02-18)
Human purine nucleoside phosphorylase has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of human PNP. Recently, several structures of human PNP have been ...
Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
Schistosomes are unable to synthesize purines de novo and depend exclusively on the salvage pathway for their purine requirements. It has been suggested that blockage of this pathway could lead to parasite death. The enzyme ...
Estrutura cristalográfica da Purina nucleosídeo foslorilase do Mycobacterium tuberculosis
(Universidade Estadual Paulista (Unesp), 2005-08-18)
A Purina Nucleosídeo Fosforilase (PNP) catalisa a fosforólise de nucleosídeos de purina para suas respectivas bases e açucares (ribose ou desoxirribose) 1-fosfato. A PNP desempenha uma função central no metabolismo das ...
Estrutura cristalográfica da Purina nucleosídeo foslorilase do Mycobacterium tuberculosis
(Universidade Estadual Paulista (Unesp), 2005-08-18)
A Purina Nucleosídeo Fosforilase (PNP) catalisa a fosforólise de nucleosídeos de purina para suas respectivas bases e açucares (ribose ou desoxirribose) 1-fosfato. A PNP desempenha uma função central no metabolismo das ...
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
(Elsevier B.V., 2014)