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Analogues of dihydrouracil and 9H-purine control Meloidogyne incognita in tomato plantsSubstâncias análogas da di-idrouracila e 9H-purina controlam Meloidogyne incognita em tomateiro
(Organizacion de Nematologos de los Tropicos Americanos (ONTA), 2018)
Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012-09-05)
The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies. ...
Developing a collection of immobilized nucleoside phosphorylases for the preparation of nucleoside analogues: Enzymatic synthesis of arabinosyladenine and 2',3'-dideoxyinosine
(Wiley, 2013-02)
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside ...
In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine
(Pergamon-Elsevier Science Ltd, 2003-12)
Administration of the adenosine analogue fludarabine (FLU) in vivo induces a profound and prolonged T lymphopenia which mainly affects CD4+ cells. To better understand the mechanistic basis underlying this preferential ...
Molecular basis of Ndt-mediated activation of nucleoside-based prodrugs and application in suicide gene therapy
(Corporación Universidad de la Costa, 2021)
Immobilization techniques applied to the development of biocatalysts for the synthesis of nucleoside analogue derivatives
(Bentham Science Publishers, 2017-12)
Abstract: Background: Nucleoside analogue (NAs) derivatives comprise a large family of pharmaceuticals clinically used as antitumoral and antiviral compounds. Originally, the production of NAs involved chemical synthesis, ...
Structure of human PNP complexed with ligands
(Blackwell Publishing, 2014)