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Combined therapy for alzheimer’s disease: Tacrine and PAMAM dendrimers co-administration reduces the side effects of the drug without modifying its activity
(Springer, 2020-03-25)
Alzheimer´s disease has become a public health priority, so an investigation of new therapies is required. Tacrine (TAC) was licensed for treatments; however, its oral administration caused hepatotoxicity, so it is essential ...
Optimization and in vitro toxicity evaluation of G4 PAMAM dendrimer–risperidone complexes
(Elsevier France-editions Scientifiques Medicales Elsevier, 2011-03)
Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein ...
Dendrimer intercalation in layered double hydroxides
(SPRINGER, 2010)
New organic/inorganic (O/I) hybrid assemblies based on Layered Double Hydroxide (LDH) with polyamide amine dendrimer (PAMAM, generation -0.5 and generation +0.5) were prepared by two different routes using either the direct ...
PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization
(Elsevier Science, 2018-06)
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient ...
Optimization and in vivo toxicity evaluation of G4.5 PAMAM dendrimer-risperidone complexes
(Public Library of Science, 2014-02)
Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein ...
Computational study adsorption of mercaptopurine in generation G3 and G5 PAMAM dendrimers
(Universidade Federal de Santa Maria, 2015)
Functionalization of PAMAM dendrimers with [Ru-III(edta)(H2O)](-)
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
The anchoring of K[Ru-III(edta)(Cl)] on poly(amidoamine) dendrimers (PAMAM of three generations G(x)/Ru (x = 0, 2 and 3)) through a peptide type bond yielded the aquo species, [Ru-III(edta)(H2O)] on dendrimer surface, and ...
Development of novel bioanodes for ethanol biofuel cell using PAMAM dendrimers as matrix for enzyme immobilization
(ELSEVIER ADVANCED TECHNOLOGY, 2011)
This paper describes the preparation and application of a novel bioanode for use in ethanol/O(2) biofuel cells based upon immobilization of alcohol dehydrogenase (ADH) and polyamidoamine (PAMAM) dendrimers onto carbon cloth ...
In vitro nanotoxicity of single-walled carbon nanotube-dendrimer nanocomplexes against murine myoblast cells
(Elsevier IrelandShannon, 2013-05)
Single-wall carbon nanotubes (SWCNTs) and polyamidoamine dendrimers (PAMAM) have been proposed for a variety of biomedical applications. The combination of both molecules makes this new composite nanomaterial highly ...