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Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-Blackwell, 2010-04-01)
Objectives Zidovudine is the antiretroviral drug most frequently used for the treatment of AIDS. Although its effectiveness is recognized, it undergoes extensive first-pass metabolism and exhibits poor oral bioavailability. ...
Obtenção, caracterização e estudo de liberação in vitro e permeação in vivo de sistemas microestruturados contendo cafeína
(Universidade Estadual Paulista (Unesp), 2006-08-07)
A mistura de óleo, água e tensoativo é capaz de formar estruturas e sistemas variados, dependendo das características e da proporção dos componentes utilizados. Sistemas microestruturados, como cristais líquidos e ...
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
(2013-05-01)
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid ...
Correlação entre estrutura e propriedades de sistemas líquidos cristalinos para a liberação prolongada de fármacos
(Universidade Estadual Paulista (Unesp), 2013-02-15)
Nas últimas décadas, têm se observado um interesse crescente na inovação de sistemas nanoestruturados utilizados para a liberação prolongada de diversas substâncias. No caso de fármacos, as formulações de liberação prolongada ...
Correlação entre estrutura e propriedades de sistemas líquidos cristalinos para a liberação prolongada de fármacos
(Universidade Estadual Paulista (Unesp), 2013-02-15)
Nas últimas décadas, têm se observado um interesse crescente na inovação de sistemas nanoestruturados utilizados para a liberação prolongada de diversas substâncias. No caso de fármacos, as formulações de liberação prolongada ...
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
(2013-05-01)
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid ...
Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de curcumina no tratamento do câncer bucal
(Universidade Estadual Paulista (Unesp), 2015-02-19)
Oral cancer is a highly incident disease in the world population and it can causes facial deformities and death. The choice treatment is costly and usually involves the administration of chemotherapy, which may have cytotoxic ...
Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-Blackwell, 2010-04-01)
Objectives Zidovudine is the antiretroviral drug most frequently used for the treatment of AIDS. Although its effectiveness is recognized, it undergoes extensive first-pass metabolism and exhibits poor oral bioavailability. ...
Development and in vitro skin delivery of dexamethasone acetate-loaded surfactant-based systems
(2013)
Topical corticosteroids, e.g., dexamethasone acetate (DMA), are extensively used to treat cutaneous inflammatory disorders even though their use is correlated with potential local and systemic side effects. The objective ...
Peptide KSL-W-loaded mucoadhesive liquid crystalline vehicle as an alternative treatment for multispecies oral biofilm
(2016-01-01)
Decapeptide KSL-W shows antibacterial activities and can be used in the oral cavity, however, it is easily degraded in aqueous solution and eliminated. Therefore, we aimed to develop liquid crystalline systems (F1 and F2) ...