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Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review
(Maney Publishing, 2010-12-01)
Objective: the present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary ...
Adrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index: A comparative study with pituitary adenomas and normal pituitary tissues
(Humana Press Inc, 1998-03-01)
Pituitary carcinomas are very rare neoplasms with a poor prognosis. We report a case of Cushing's disease resulting from a pituitary carcinoma in a ZZ-yr-old female, who died of massive hepatic failure. At autopsy, there ...
Novel Medical Therapies for Pituitary Tumors
(Karger, 2010-07)
Despite considerable progress, there is still no medical treatment available for some kinds of pituitary tumors, in particular hormone inactive adenomas and corticotroph pituitary tumors. Surgical removal or at least ...
Frequency of multiple endocrine neoplasia type 1 in a group of patients with pituitary adenoma: genetic study and familial screening
(2013-01-18)
The purpose of this study it was to evaluate the frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those individuals afflicted ...
Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
(Sociedade Brasileira de Endocrinologia e Metabologia, 2011-06-01)
OBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal ...
Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas
(Associação Brasileira de Divulgação Científica, 2012)
The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding ...
Pure endoscopic transsphenoidal surgery for treatment of acromegaly: results of 67 cases treated in a pituitary center
(Amer Assoc Neurological SurgeonsRolling MeadowsEUA, 2010)