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Cyclosporin but not tacrolimus significantly increases salivary cytokine contents in rats
(2005-09-01)
Background: Cyclosporin (CsA) and tacrolimus (FK-506) are immunosuppressive drugs that specifically inhibit T-cell activation via calcineurin inhibition. Gingival overgrowth is a common side effect following the administration ...
Eritema multiforme limitado à cavidade oral em um cão
(Universidade Federal de Santa MariaBrasilUFSMCentro de Ciências Rurais, 2015-03-05)
Erythema multiforme is an uncommon disease in dogs that affects the skin and mucous membranes, whose etiology has not been fully elucidated. This paper describes a case of erythema multiforme limited to the oral cavity in ...
Cyclosporine A – Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis
(2019-01-01)
The most important microscopic characteristic of Cyclosporine A-induced gingival overgrowth is fibroepithelial hyperplasia. Objective: The objective was to investigate the influence of previous exposure to Cyclosporine A ...
Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes
(2020-01-01)
The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two ...
Oral Lesions in Renal Transplant
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2013-08-02)
To prevent rejection of kidney transplants, patients must be kept in immunosuppressive therapy for a long time, which includes the use of drugs such as cyclosporine, azathioprine, cyclophosphamide, and prednisone. The ...
Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): Histochemical and MMP-1 and -2 and collagen I gene expression analyses
(Amer Acad Periodontology, 2008-01-01)
Background: The purpose of this experimental study was to evaluate the collagen fiber distribution histologically after phenytoin, cyclosporin, or nifedipine therapy and to correlate it with collagen I and matrix ...
Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): Histochemical and MMP-1 and -2 and collagen I gene expression analyses
(Amer Acad Periodontology, 2008-01-01)
Background: The purpose of this experimental study was to evaluate the collagen fiber distribution histologically after phenytoin, cyclosporin, or nifedipine therapy and to correlate it with collagen I and matrix ...
Influence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbits
(Blackwell Publishing, 2007-02-01)
To evaluate the influence of cyclosporin A (CsA) administration on bone around integrated dental implants assessed by a bone quality index and by quantitative subtraction radiography.A total of 36 machine surface commercial ...
Effects of long-term cyclosporin therapy on gingiva of rats--analysis by stereological and biochemical estimation.
(2005-04-01)
Cyclosporin A (CsA) is used as an immunosuppressive agent and its prominent side effect is the induction of gingival overgrowth, which remains a significant problem. The risk factors appraised include the duration of ...
Effects of long-term cyclosporin therapy on gingiva of rats--analysis by stereological and biochemical estimation.
(2005-04-01)
Cyclosporin A (CsA) is used as an immunosuppressive agent and its prominent side effect is the induction of gingival overgrowth, which remains a significant problem. The risk factors appraised include the duration of ...