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Sulforaphane is anticonvulsant and improves mitochondrial function
(Wiley & Sons, 2015)
The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to
protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator
sulforaphane in various ...
Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-kappa B and Nrf2
(Elsevier, 2016)
The aim of this study was to determine the gastrointestinal protection by quercetin against indomethacin-induced oxidative stress and inflammation, with specific interest in studying the underlying molecular mechanisms. ...
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders
Systems medicine is founded on a mechanism-based approach and identifies in this way
specific therapeutic targets. This approach has been applied for the transcription factor nuclear
factor (erythroid-derived 2)–like 2 ...
The organophosphate chlorpyrifos disturbs redox balance and triggers antioxidant defense mechanisms in JEG-3 cells
(Elsevier, 2013-07)
Introduction: Reactive oxygen species (ROS) are produced by a number of physiological and pathological processes which influence the function of a diverse array of cellular events. An imbalance between ROS generation and ...
Manipulating the exposome to enable better ageing
(Portland Press, 2021)
The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ...
Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice
(Elsevier Inc, 2015-04)
Changes in expression of liver ABC transporters have been described during acute APAP intoxication. However, the effect of APAP on brain ABC transporters is poorly understood. The aim of this study was to evaluate the ...
Efeito protetor do exercício físico nas alterações bioquímicas e cognitivas iniciais e tardias induzidas pelo traumatismo cranioencefálico em ratos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2014-08-23)
Traumatic brain injury (TBI) is a major cause of morbidity and mortality in industrialized countries leading to the motor and cognitive deficits. Evidence demonstrated that exercise is neuroprotective in traumatic brain ...
Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis
(Academic Press Inc Elsevier Science, 2017-01)
Molecular mechanisms on sepsis progression are linked to the imbalance between reactive oxygen species (ROS) production and cellular antioxidant capacity. Previous studies demonstrated that benznidazole (BZL), known for ...