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In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia
(Humana Press, 2018)
Sensory neurons from dorsal root ganglion efficiently regenerate after peripheral nerve injuries. These neurons are widely used as a model system to study degenerative mechanisms of the soma and axons, as well as regenerative ...
The insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neurons
(Public Library Science, 2013-01)
Axonal regeneration is an essential condition to re-establish functional neuronal connections in the injured adult central nervous system (CNS), but efficient regrowth of severed axons has proven to be very difficult ...
Diapause induces functional axonal regeneration after necrotic insult in C. elegans
(PUBLIC LIBRARY SCIENCE, 2019)
Many neurons are unable to regenerate after damage. The ability to regenerate after an insult depends on life stage, neuronal subtype, intrinsic and extrinsic factors. C. elegans is a powerful model to test the genetic and ...
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration
(Public Library Science, 2015)
ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes
disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle.
ERp57 is markedly upregulated in most common ...
Decreased MHC I expression in IFN gamma mutant mice alters synaptic elimination in the spinal cord after peripheral injury
(Biomed Central LtdLondonInglaterra, 2012)
Molecular complexity of visual mapping: A challenge for regenerating therapy
(Shenyang Editorial Dept Neural Regeneration Res, 2019-09)
Investigating the cellular and molecular mechanisms involved in the development of topographically ordered connections in the central nervous system constitutes an important issue in neurobiology because these connections ...
Should mast cells be considered therapeutic targets in multiple sclerosis?
(2020-11-01)
Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and ...
Mitochondrial function in spinal cord injury and regeneration
(SPRINGER BASEL AG, 2022)
Many people around the world suffer from some form of paralysis caused by spinal cord injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of the central nervous system (CNS), which in ...
Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae.
(2014)
Background: Peripheral nerve injuries can severely affect the way that animals perceive signals from the surrounding environment. While damage to peripheral axons generally has a better outcome than injuries to central ...
Bursting the unfolded protein response accelerates axonal regeneration
(2016)
Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system (PNS) is damaged. These pathological state are are associated with weakness, pain, and loss of motor and sensory control. More ...