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Potent mutagenicity in the Ames test of 2-cyano-4-nitroaniline and 2,6-dicyano-4-nitroaniline, components of disperse dyes
(Wiley-Blackwell, 2015-09-22)
Genotoxicity data on commercial azo dyes and their components remain sparse, despite their widespread use. We have tested the mutagenicity of 2-cyano-4-nitroaniline (CNNA) and 2,6-dicyano-4-nitroaniline (CNCNNA), components ...
Evaluating 5-Nitrothiazoles as Trypanocidal Agents
(Amer Soc Microbiology, 2016)
The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma
brucei. A subset of related compounds displayed the greatest potency toward the parasite while
exhibiting little cytotoxic ...
Alteraciones ultraestructurales en la mucosa del colon de ratas tratadas con nifurtimoxUltrastructural alterations in colonic mucosa of nifurtimox treated rats
(Medicina (Buenos Aires), 2001-12)
El nifurtimox (Nfx) es un fármaco empleado en el tratamiento del Mal de Chagas agudo que ha evidenciado en su uso clínico y en estudios experimentales efectos colaterales tóxicos que comprometen su empleo. Estos efectos ...
Identificação, caracterização e recuperação de aminas aromáticas presentes em água vermelha
(Universidade Tecnológica Federal do ParanáPato Branco, 2014)
During the industrial process for manufacture of TNT, asymmetric TNTs are produced from the nitration of toluene, and must be removed to meet military specifications. The three-nitro compound is formed with several impurities, ...
The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824
(PERGAMON-ELSEVIER SCIENCE LTD, 2011-01-15)
Nitroimidazole PA-824 is part of an exciting new class of compounds currently undergoing clinical evaluation as novel TB therapeutics. The recently elucidated mechanism of action of PA-824 involves reduction of the ...
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents
(American Chemical Society, 2015)
3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogues were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for ...
Voltammetric redox behavior of nitrofuryl 1,4-dihydropyridine derivatives: Interdependence between two redox centers
(ELSEVIER SCIENCE SA, 2006-06-01)
To investigate new chemotherapeutics alternatives to Chagas' disease, three 4-(5'-nitro-2'-furyl)-1,4-dihydropyridine derivatives were synthesized and electrochemically investigated in order to clarify their redox behavior. ...
Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole MetabolismPutative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole MetabolismPutative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole MetabolismPutative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole MetabolismPutative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism
(American Society for MicrobiologyAmerican Society for MicrobiologyAmerican Society for MicrobiologyAmerican Society for MicrobiologyAmerican Society for Microbiology, 2016-05)
Benznidazole (Bz), the drug used for treatment of Chagas' disease (caused by the protozoan Trypanosoma cruzi), is activated by a parasitic NADH-dependent type I nitroreductase (NTR I). However, several studies have shown ...
Differential Toxicity of Disperse Red 1 and Disperse Red 13 in the Ames Test, HepG2 Cytotoxicity Assay, and Daphnia Acute Toxicity Test
(WILEY-BLACKWELL, 2011)
Azo dyes are of environmental concern due to their degradation products, widespread use, and low-removal rate during conventional treatment. Their toxic properties are related to the nature and position of the substituents ...
Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
(Public Library Of Science, 2014-05)
Background
The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug ...