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Chaperoning a7 neuronal nicotinic acetylcholine receptors
(Elsevier, 2012-03)
The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cysloop family of receptors present in the central nervous system. It participates in various physiological processes ...
alpha 4 beta 2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
(AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2006-08)
Alpha 4 and beta 2 nicotinic acetylcholine receptor ( nAChR) subunits expressed heterologously assemble into receptors with high (HS) and low (LS) sensitivity to acetylcholine (ACh); their relative proportions depend on ...
Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors
(2001)
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisine (3,5-diBr-cy) on human (h) α7-, α4β2- and α4β4 nicotinic acetylcholine (nACh) receptors, expressed in Xenopus oocytes ...
Methylpiperidinium Iodides as novel antagonists for alpha 7 nicotinic acetylcholine receptors
(Frontiers Media, 2018)
The alpha 7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target. We have designed and ...
A necessary connection: cholesterol and nicotinic receptors
(Sociedad Argentina de Biofísica, 2019)
It is known that the muscle nicotinic acetylcholine receptor (nAChR) is highly influenced by its lipid environment. It is present in high-density clusters in the muscle cell membrane where it localizes mainly in liquid-ordered ...
Stoichiometry for activation of neuronal alpha7 nicotinic receptors
(National Academy of Sciences, 2013-12)
Neuronal α7 nicotinic receptors elicit rapid cation influx in response to acetylcholine (ACh) or its hydrolysis product choline. They contribute to cognition, synaptic plasticity, and neuroprotection and have been implicated ...
(−)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites
(Elsevier, 2013-07)
The interaction of (−)-reboxetine, a non-tricyclic norepinephrine selective reuptake inhibitor, with muscle-type nicotinic acetylcholine receptors (AChRs) in different conformational states was studied by functional and ...
Is the antidepressant activity of selective serotonin reuptake inhibitors mediated by nicotinic acetylcholine receptors?
(Molecular Diversity Preservation International, 2021-04)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates ...
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
(Elsevier Science, 2010-05-03)
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied ...