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NFAT Isoforms Regulate Muscle Fiber Type Transition without Altering CaN during Aerobic Training
(Georg Thieme Verlag KgStuttgartAlemanha, 2013)
Nuclear factor of activated T cells-dependent downregulation of the transcription factor glioma-associated protein 1 (GLI1) underlies the growth inhibitory properties of arachidonic acid
(American Society for Biochemistry and Molecular Biology, 2016-01)
Numerous reports have demonstrated a tumor inhibitory effect of polyunsaturated fatty acids (PUFAs). However, the molecular mechanisms modulating this phenomenon are in part poorly understood. Here, we provide evidence of ...
Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells
(Nature Publishing Group, 2007-02)
Cyclooxygenase-2 (Cox-2), the gastrin-release peptide (GRP) and its cognate receptor (GRP-R) are overexpressed in a significant percentage of colorectal carcinomas and are associated with cell growth, invasiveness and tumor ...
Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Cardiomyocyte hypertrophy occurs in response to a variety of physiological and pathological stimuli. While pathological hypertrophy in heart failure is usually coupled with depressed contractile function, physiological ...
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries
(National Academy of Sciences, 2017)
Abstract: The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death by apoptopic and necrotic ...
Participación de la vía GSK3-[beta]/NFAT en la hipertrofia inducida por testosterona del cardiomiocito de rata neonata
(Universidad de ChileCyberDocs, 2011)
El uso de elevadas dosis de testosterona produce hipertrofia cardiaca, sin embargo los mecanismos celulares no son completamente entendidos. La proteína quinasa GSK3-β (glycogen synthase kinase 3-β) es una quinasa que ...
Papel del factor transcripcional TonEBP en el daño cardíaco inducido por hiperosmolaridad
(Universidad de Chile, 2009)
TonEBP, la proteína que se une al elemento regulatorio que responde a tonicidad “TonE” es el único factor transcripcional conocido de eucariontes que responde a cambios de la osmolaridad extracelular. Este factor transcripcional ...
Potencial da aplicação tópica de um novo composto chalcônico na modulação da periodontite em ratos
(Universidade Estadual Paulista (Unesp), 2022-03-16)
As chalconas são um grupo de compostos fenólicos derivados de plantas, com diversas propriedades biológicas. Em função dos seus efeitos farmacológicos (atividade anti-inflamatória, antioxidante, anti-osteolítica) e baixa ...
Efeito de uma nova Chalcona sobre a reabsorção óssea inflamatória: estudo in vitro e in vivo
(Universidade Estadual Paulista (Unesp), 2020-03-26)
As chalconas são um grupo de compostos fenólicos derivados de plantas, com diversas propriedades biológicas. Em função dos seus efeitos farmacológicos, diferentes derivados chalcônicos sintéticos, baseados em seus análogos ...
Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy
(Fundação Oswaldo Cruz, 2018-07)
BACKGROUND The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on ...