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Mostrando ítems 21-30 de 1422
Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis
(Wiley-BlackwellHoboken, 2012)
An ERcentric view of Parkinson's disease
(2013)
Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
Targeting autophagy in ALS: A complex mission
(Taylor and Francis Inc., 2011)
Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study
(Springer, 2015)
Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal ...
DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria
(2019)
Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved ...
Basis of progesterone protection in spinal cord neurodegeneration
(Pergamon-Elsevier Science Ltd., 2003-01)
Progesterone neuroprotection has been reported in experimental brain, peripheral nerve and spinal cord injury. To investigate for a similar role in neurodegeneration, we studied progesterone effects in the Wobbler mouse, ...
Fluoro-Jade, but not Fluoro-Jade B, stains non-degenerating cells in brain and retina of embryonic and neonatal rats
(Elsevier Science BvAmsterdamHolanda, 2004)
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
(Wiley, 2018-06)
Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins ...