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Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons
(Wiley Blackwell Publishing, Inc, 2014-06)
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in food intake and energy expenditure regulation. MC4R activation modifies neuronal activity but the molecular mechanisms by which this regulation ...
Calcium channel subtypes differentially regulate fusion pore stability and expansion
(2007)
Various studies have focused in the relative contribution of different voltage-activated Ca2+ channels (VACC) to total transmitter release. However, how Ca2+ entry through a given VACC subtype defines the pattern of ...
Expression and characterization of LTx2, a neurotoxin from Lasiodora sp effecting on calcium channels
(ELSEVIER SCIENCE INC, 2008)
Here, we described the expression and characterization of the recombinant toxin LTx2, which was previously isolated from the venomous cDNA library of a Brazilian spider, Lasiodora sp. (Mygalomorphae, Theraphosidae). The ...
L-Type Calcium Channels Modulation by Estradiol
(2017-09-01)
Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the ...
UBE2L3 participates of the ubiquitination and proteasomal degradation of N-type Voltage-gated calcium channel.
(2017)
The modification of proteins with ubiquitin is a critical event that determines the fate of many proteins in the
cell. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ...