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Ionotropic but not metabotropic glutamatergic receptors in the locus coeruleus modulate the hypercapnic ventilatory response in unanaesthetized rats
(2013-05-01)
Aim: Central chemoreceptors are important to detect changes of CO2/H+, and the Locus coeruleus (LC) is one of the many putative central chemoreceptor sites. Here, we studied the contribution of LC glutamatergic receptors ...
Ionotropic but not metabotropic glutamatergic receptors in the locus coeruleus modulate the hypercapnic ventilatory response in unanaesthetized rats
(2013-05-01)
Aim: Central chemoreceptors are important to detect changes of CO2/H+, and the Locus coeruleus (LC) is one of the many putative central chemoreceptor sites. Here, we studied the contribution of LC glutamatergic receptors ...
Dopamine partial agonist actions of the glutamate receptor agonists LY 354,740 and LY 379,268
(Veterinary and Human Toxicology, 2008-02)
Because glutamate compounds alter the release of dopamine and prolactin, the present study examined whether group II metabotropic receptor agonists, LY 354,740 and LY 379,268, had any direct in vitro action on dopamine D2 ...
Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors
(Pergamon-Elsevier Science Ltd, 2017-09)
Astrocytes are now fully endorsed as key players in CNS functionality and plasticity. We recently showed that metabotropic glutamate receptor 3 (mGlu3R) activation by LY379268 promotes non-amyloidogenic cleavage of amyloid ...
From glutamatergic dysfunction to cognitive impairment: Boundaries in the therapeutic of the schizophrenia
(Bentham Science, 2012)
Cognitive deficits are trait markers in schizophrenia and the improvement of these dysfunctions has been considered as a new frontier of treatment in this disease. A current model for the patophysiology of schizophrenia ...
Glutamate Induces Apoptosis in Anterior Pituitary Cells through Group II Metabotropic Glutamate Receptor Activation
(Endocrine Society, 2004-10)
Glutamate can induce neuronal cell death by activating ionotropic glutamate receptors (iGluRs) as well as metabotropic glutamate receptors (mGluRs). In the present study, we investigated whether glutamate induces apoptosis ...
Role of metabotropic glutamate receptors in the control of neuroendocrine function.
(Pergamon-Elsevier Science Ltd, 2008-12)
Glutamate exerts its effects through binding and activation of two classes of specific receptors: ionotropic (iGluRs) and metabotropic (mGluRs). Group I mGluR includes mGluR1 and mGluR5 subtypes, group II includes mGluR2 ...