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Dengue fusion peptides in interaction with model membranes-A fluorescence study
(2021-04-01)
Dengue fever is a widespread infectious disease caused by Dengue viruses and responsible for millions of cases per year. One of the key steps during the infection is the fusion between the cell membrane and the lipidic ...
Interaction of biologically-relevant peptides with membrane model systems
(2011)
In this work, we monitor the alterations caused in membrane model systems upon the addition of biologically-relevant peptides. Our first study reports on the interaction with model membranes of an internal fusion peptide ...
Antimicrobial Peptide K0-W6-Hya1 Induces Stable Structurally Modified Lipid Domains in Anionic Membranes
(2018-02-06)
Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) ...
Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length
(Molecular Diversity Preservation International, 2017-07)
A set of lipopeptides was recently reported for their broad-spectrum antiviral activity against viruses belonging to the Paramyxoviridae family, including human parainfluenza virus type 3 and Nipah virus. Among them, the ...
Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction
(Elsevier B.V., 2017-11-01)
Background: Leishmaniasis threatens poor areas population worldwide, requiring new drugs less prone to resistance development. Antimicrobial peptides with antileishmanial activity are considered among fulfilling alternatives, ...
Study of the mechanism of action of anoplin, a helical antimicrobial decapeptide with ion channel-like activity, and the role of the amidated C-terminus
(John Wiley & Sons Ltd, 2008-06-01)
Anoplin, an antimicrobial, helical decapeptide from wasp venom, looses its biological activities by mere deamidation of its C-terminus. Secondary structure determination, by circular dichroism spectroscopy in amphipathic ...
Study of the mechanism of action of anoplin, a helical antimicrobial decapeptide with ion channel-like activity, and the role of the amidated C-terminus
(John Wiley & Sons Ltd, 2008-06-01)
Anoplin, an antimicrobial, helical decapeptide from wasp venom, looses its biological activities by mere deamidation of its C-terminus. Secondary structure determination, by circular dichroism spectroscopy in amphipathic ...
Structure-Activity Relationship of the Antimicrobial Peptide Gomesin: the Role of Peptide Hydrophobicity in Its Interaction with Model Membranes
(Amer Chemical Soc, 2014-04-01)
Antimicrobial peptides are part of the innate immune system of animals and plants. Their lytic activity against microorganisms generally depends on their ability to disrupt and permeabilize membranes. Here we study the ...