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Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
(Nature Publishing Group, 2021)
Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation ...
Refinement of neuronal synchronization with gamma oscillations in the medial prefrontal cortex after adolescence
(Public Library of Science, 2013-04)
The marked anatomical and functional changes taking place in the medial prefrontal cortex (PFC) during adolescence set grounds for the high incidence of neuropsychiatric disorders with adolescent onset. Although circuit ...
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats
(Elsevier B.V., 2017-12-01)
Retrospective studies in human populations indicate that protein deprivation during pregnancy and early life (early protein malnutrition, EPM) is associated with cognitive impairments, learning disabilities and may represent ...
Increase in medial frontal cortex ERK activation following the induction of apomorphine sensitization
(Elsevier B.V., 2014-03-01)
Repeated high dose injections of the direct acting D1/D2 agonist apomorphine (APO) induces context specific behavioral sensitization. We assessed the effects of 2.0 mg/kg APO on open-field locomotor responses of rats over ...
Processamento da memória de medo: dimorfismo sexual e consolidação tardia na amígdala e no córtex pré-frontal medial
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-05-14)
Not all memories last for the lifetime. Generally speaking, memories with high emotional value during acquisition tend to remain accessible for longer periods. However, the mechanisms that interfere with memory endurance ...
Susceptibility to extinction and reinstatement of ethanol-induced conditioned place preference is related to differences in astrocyte cystine-glutamate antiporter content
(2020-01-01)
Individual susceptibility to alcohol effects plays an important role in the development of alcohol addiction and studies have shown that glutamate release is altered after chronic ethanol consumption. The cystine-glutamate ...
Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior
(2017)
The prelimbic area (PL) of the medial Prefrontal cortex (mPFC) is involved in the acquisition and expression of conditioned and innate fear. Both types of fear share several neuronal pathways. It has been documented that ...