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Mostrando ítems 21-30 de 308
Caracterización molecular y análisis evolutivo del complejo mayor de histocompatibilidad clase I (MHC-I) en primates del nuevo mundo (Platyrrhini)
(2014)
El complejo mayor de histocompatibilidad clase I (MHC-I) codifica para proteínas de membrana que presentan péptidos antigénicos a los linfocitos T citotóxicos que inician la respuesta inmune celular [1]. El MHC-I se ha ...
Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule
(Amer Assoc Immunologists, 2014-11)
MHC class I molecules (HLA-I in humans) present peptides derived from endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and -B molecules have been studied extensively, little is known about ...
Unconventional peptide presentation by major histocompatibility complex (MHC) class i allele HLA-A∗02:01: Breaking confinement
(American Society for Biochemistry and Molecular Biology, 2017-03)
Peptide antigen presentation by major histocompatibility complex (MHC) class I proteins initiates CD8+ T cell-mediated immunity against pathogens and cancers.MHCI molecules typically bind peptides with 9 amino acids in ...
In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
(Frontiers Research Foundation, 2023)
Automated benchmarking of peptide-MHC class i binding predictions
(Oxford University Press, 2015-07)
Motivation: Numerous in silico methods predicting peptide binding to major histocompatibility complex (MHC) class I molecules have been developed over the last decades. However, the multitude of available prediction tools ...
Identification and evaluation in-vitro of conserved peptides with high affinity to MHC-I as potential protective epitopes for Newcastle disease virus vaccines
(BioMed Central, 2023)
Background: Newcastle disease (ND) is a major threat to the poultry industry, leading to significant economic losses. The current ND vaccines, usually based on active or attenuated strains, are only partially effective and ...
Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation
(Wiley, 2017)
Dendritic cells (DCs) are the major professional APCs of the immune system; however, their MHC-II-associated peptide repertoires have been hard to analyze, mostly because of their scarce presence in blood and tissues. In ...
Footprints of antigen processing boost MHC class II natural ligand predictions
(Springer Nature, 2018-11)
BACKGROUND: Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, ...
NNAlign-MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved t-cell epitope predictions
(American Society for Biochemistry and Molecular Biology, 2019-10)
The set of peptides presented on a cell´s surface by MHC molecules is known as the immunopeptidome. Current mass spectrometry technologies allow for identification of large peptidomes, and studies have proven these data ...