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mGlu3 receptor and astrocytes: Partners in neuroprotection
(Elsevier, 2013-03)
Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation ...
Ionotropic but not metabotropic glutamatergic receptors in the Locus Coeruleus modulate the hypercapnic ventilatory response in unanesthetized rats
(Federation Amer Soc Exp Biol, 2014)
mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea
(Wiley Blackwell Publishing, Inc, 2017-06-01)
Key points: Spontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (afferent) auditory system before hearing begins. Just before the onset of hearing, descending (efferent) input ...
Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
From glutamatergic dysfunction to cognitive impairment: Boundaries in the therapeutic of the schizophrenia
(Bentham Science, 2012)
Cognitive deficits are trait markers in schizophrenia and the improvement of these dysfunctions has been considered as a new frontier of treatment in this disease. A current model for the patophysiology of schizophrenia ...
Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor
(Springer Nature Switzerland, 2021-05-24)
The α7 nicotinic acetylcholine receptor is involved in neurological, neurodegenerative, and inflammatory disorders. It operates both as a ligand-gated cationic channel and as a metabotropic receptor in neuronal and ...
D4 dopamine and metabotropic glutamate receptors in cerebral cortex and striatum in rat brain
(Springer/Plenum Publishers, 2001-01)
The characterization of the functional interactions between the metabotropic glutamate receptors (mGluR) and the dopaminergic (DR) receptors in the corticostriatal projections may provide a possible interpretation of ...