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Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D
(2017-04-01)
Loxoscelism refers to the clinical symptoms that develop after brown spider bites. Brown spider venoms contain several phospholipase-D isoforms, which are the main toxins responsible for both the cutaneous and systemic ...
Tetracycline and penicillin resistant clostridium perfringens isolated from the fangs and venom glands of loxosceles laeta: its implications in loxoscelism treatment
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
The venom of Loxosceles spiders produces severe dermonecrotic damage, intravascular hemolysis, systemic alterations and risk of death. Clostridium perfringens is present in the microbial flora of the fangs and venom glands ...
Avaliação das Populações de Aranhas do Gênero loxosceles (Araneae; Sicariidae), no Município de Rio Branco do Sul, Paraná, Brasil
(Universidade Federal de Santa Maria, 2010)
Characterization of Brown spider (Loxosceles intermedia) hemolymph: Cellular and biochemical analyses
(Elsevier B.V., 2015-05-01)
This is the first study on the hemolymph from a spider of the Loxosceles genus. These animals are responsible for a great number of envenomation cases worldwide. Several studies on Loxosceles venoms have been published, ...
Determination of the maximum and minimum lethal temperatures (LT50) for Loxosceles intermedia Mello-Leitao, 1934 and L-laeta (Nicolet, 1849) (Araneae, Sicariidae)
(Pergamon-elsevier Science LtdOxfordInglaterra, 2003)
A protective vaccine against the toxic activities following Brown spider accidents based on recombinant mutated phospholipases D as antigens
(2021-12-01)
Accidents involving Brown spiders are reported throughout the world. In the venom, the major toxins involved in the deleterious effects are phospholipases D (PLDs). In this work, recombinant mutated phospholipases D from ...
Relação mecanística entre a atividade fosfolipásica e os efeitos tóxicos induzidos pela toxina dermonecrótica do veneno de aranha marrom (Loxosceles intermedia)
(Universidade Federal de São Paulo (UNIFESP), 2009)
Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from Brown spider (Loxosceles intermedia) venom: From cloning to functional characterization
(Elsevier B.V., 2007-03-01)
Loxoscelism (the condition produced by the bite of brown spiders) has been reported worldwide, but especially in warmer regions. Clinical manifestations include skin necrosis with gravitational spreading while systemic ...
Brown spider venom toxins interact with cell surface and are endocytosed by rabbit endothelial cells
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Bites from the Loxosceles genus (brown spiders) cause severe clinical symptoms, Including dermonecrotic injury, hemorrhage, hemolysis, platelet aggregation and renal failure. Histological findings of dermonecrotic lesions ...