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Isolated trisomy 11 in de novo acute myeloid leukemia
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2008-01-01)
The real mechanism involved in trisomies and leukemogenesis remains unknown and more information about this connection is essential, but unfortunately the clinical outcome and hematological profile of patients with isolated ...
RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM)
(Elsevier Inc, 2017-04)
In this review, we discuss disease-causing alterations of RUNT-related transcription factor 1 (RUNX1), a master regulator of hematopoietic differentiation. Familial platelet disorder with predisposition to myeloid leukemia ...
Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies
(Pergamon-Elsevier B.V. Ltd, 2011-05-01)
Indole-3-acetic acid (IAA), when oxidized by horseradish peroxidase (HRP), is transformed into cytotoxic molecules capable of inducing cell injury. The aim of this study was to test if, by targeting hematopoietic tumors ...