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Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta
(Walter de Gruyter & Co, 2009-09-01)
Bradykinin (BK) is a vasorelaxant, algesic and inflammatory agent. Angiotensin II (AngII) is known to control vascular tone and promote growth, inflammation and artherogenesis. There is evidence for cross talking between ...
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy
(Elsevier B.V., 2004-04-23)
Kinins, a special class of polypeptides, are represented by bradykinin (BK), kallidin (Lys-BK), as well as their metabolites. the biological actions of these polypeptides binding on their receptors (B1 and B2) have been ...
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells
(Society of Biology of Chile, 2002)
Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells
(Sociedad de Biología de Chile, 2002)
Altered Glucose Homeostasis and Hepatic Function in Obese Mice Deficient for Both Kinin Receptor Genes
(Public Library Science, 2012-07-19)
The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and ...
Altered Glucose Homeostasis and Hepatic Function in Obese Mice Deficient for Both Kinin Receptor Genes
(Public Library Science, 2012-07-19)
The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and ...
Kinin B1 receptors facilitate the development of temporal lobe epilepsy in mice
(Elsevier B.V., 2008-02-01)
Kinins may play a relevant role in epilepsy. in the present study, we evaluated the hippocampal expression of the remaining kinin receptor in 131 (B1KO) and B2 (B2KO) knockout mice strains during the development of pilocarpine ...
A possible alternative mechanism of kinin generation in vivo by cathepsin L
(Walter de Gruyter & Co, 2005-07-01)
We investigated the ability of cathepsin L to induce a hypotensive effect after intravenous injection in rats and correlated this decrease in blood pressure with kinin generation. Simultaneously with blood pressure decrease, ...