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Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement
(Phytochemistry, 2013)
The plant Cecropia pachystachya Trécul is widely used in Brazilian ethnomedicine to treat hypertension,
asthma, and diabetes. Arginase is an enzyme with levels that are elevated in these disorders, and it is central
to ...
DNA polimerase beta: uma proteína envolvida na replicação e reparo do DNA mitocondrial emTrypanosoma cruzi
(Universidade Federal de Minas GeraisUFMG, 2010-03-19)
During its life cycle, the causative agent of Chagas Disease Trypanosoma cruzi must deal with the deleterious action of reactive oxygen species (ROS) on DNA, mainly 7,8-dihydro-8-oxoguanine (8oxoG). If unrepaired, 8oxoG ...
Molecular epidemiology and diagnosis of Leishmania: What have we learnt from genome structure and function?
(Oxford University Press, 2002)
This paper reviews our exploration of the dynamics of the Leishmania genome and its contribution to epidemiology and diagnosis. We used as a model Peruvian populations of L. (Viannia) braziliensis and L. (V.) peruviana, 2 ...
Dual cellular localization of the Leishmania amazonensis Rbp38 (LaRbp38) explains its affinity for telomeric and mitochondrial DNA
(2019-07-01)
Rbp38 is a protein exclusively found in trypanosomatid parasites, including Leishmania amazonensis, the etiologic agent of tegumentar leishmaniasis in the Americas. The protein was first described as a Leishmania tarentolae ...
An improved silver staining procedure for schizodeme analysis in polyacrylamide gradient gels
(Fundação Oswaldo Cruz, 2016)
Characterization of Chilean, Bolivian, and Argentinian Trypanosoma cruzi populations by restriction endonuclease and isoenzyme analysis
(1992)
Ninety-one Chilean, 15 Bolivian, and 9 Argentinian Trypanosoma cruzi stocks, isolated from various hosts and vectors, were characterized by schizodeme analysis with EcoRI and MspI endonucleases. The three major similar ...
Evaluation of Nifurtimox Treatment of Chronic Chagas Disease by Means of Several Parasitological Methods
(American Society for Microbiology, 2013-09)
Currently, evaluation of drug efficacy for Chagas disease remains a controversial issue with no consensus. In this work, we evaluated
the parasitological efficacy of Nifurtimox treatment in 21 women with chronic Chagas ...
Description of Leishmania (Leishmania) forattinii sp. n., a new parasite infecting opossums and rodents in Brazil
(Instituto Oswaldo Cruz, Ministério da Saúde, 1993-09-01)
A new parasite species of Leishmania is described, L. (Leishmania) forattinii sp. n., which was isolated from a pooled triturate of liver and spleen of a opossum (Didelphis marsupialis aurita) and from skin samples from a ...