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Intranasal administration of TLR agonists induces a discriminated local innate response along murine respiratory tract
(Elsevier Science, 2015-03)
Adjuvants are relevant for mucosal immunization in order to induce long lasting protective immunity. It has been shown that targeting to different regions of the airway results in different capacity to trigger adaptive/protective ...
Comparação entre as vias intranasal e intramuscular para a imunização com uma vacina de antígeno bruto de Staphylococcus aureus
(3014-04-30)
A mastite é uma enfermidade da glândula mamária que se caracteriza por um processo inflamatório, quase sempre decorrente da presença de microrganismos infecciosos. É considerada a principal causa de perdas econômicas ...
Avaliação da imunidade protetora induzida pela vacinação intranasal com adenovirus recombinante contendo gene da trans-sialidase
(Universidade Federal de São Paulo (UNIFESP), 2019-10-30)
Chagas’ disease is caused by the intracellular agent Trypanosoma cruzi. Estimates indicate that 8 million people are infected worldwide, and in Brazil that is over 1 million people are infected with T. cruzi. The course ...
Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic Trypanosoma cruzi immunity involving CD8(+) CTL and B cell-mediated cross-priming
(Amer Assoc Immunologists, 2007-11-15)
The Trypanosoma cruzi trans-sialidase (TS) is a unique enzyme with neuraminidase and sialic acid transfer activities important for parasite infectivity. The T. cruzi genome contains a large family of TS homologous genes, ...
Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal colonization and renal damage caused by Shiga toxin-producing Escherichia coli
(Nature, 2020)
Shiga toxin-producing Escherichia coli (STEC) cause diarrhea and dysentery, which may progress to hemolytic uremic syndrome (HUS). Vaccination has been proposed as a preventive approach against STEC infection; however, ...
Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection
(Hindawi Publishing Corporation, 2014)
The intranasal vaccination of pregnant dams with Intimin and EspB confers protection in neonatal mice from Escherichia coli (EHEC) O157: H7 infection
(Elsevier, 2016-05)
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is responsible for intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. In this study, we evaluated ...