Buscar
Mostrando ítems 21-30 de 183
Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis
(ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013)
A flow cytometer-based method to simultaneously assess activity and selectivity of compounds against the intracellular forms of Trypanosoma cruzi
(Elsevier Science, 2015-12-10)
Chagas disease is a major unsolved health issue in Latin America and an emerging threat worldwide. New drugs are urgently needed for chemotherapy as those available (benznidazole and nifurtimox) have variable efficacy and ...
Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis
(BioMed Central, 2016)
Abstracts
Background
American tegumentary leishmaniasis (ATL) in Brazil is mostly caused by Leishmania (Viannia) braziliensis, with known forms of the disease being cutaneous ...
Development of a Fluorescent Assay to Search New Drugs Using Stable tdTomato-Leishmania, and the Selection of Galangin as a Candidate With Anti-Leishmanial Activity
(Frontiers Media, 2021-06-04)
Antimonials continue to be considered the first-line treatment for leishmaniases, but its use entails a wide range of side effects and serious reactions. The search of new drugs requires the development of methods more ...
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata
(2017-03-01)
The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Several bioactivities have been described in extracts ...
Germacranolide-type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana and Trypanosoma cruzi
(BioMed Central, 2017-11)
Background: Leishmaniasis and Chagas disease are life-threatening illnesses caused by the protozoan parasites Leishmania spp. and Trypanosoma cruzi, respectively. They are known as "neglected diseases" due to the lack of ...
Participação das proteínas ezrina, radixina e moesina (ERM proteins) na invasão celular por amastigotas extracelulares de Trypanosoma cruzi
(Universidade Federal de São Paulo (UNIFESP), 2016-11-30)
The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas? disease that affects 6-7 million people worldwide, mostly in the South and Central America. Chagas? disease was responsible for 76% of all deaths ...