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Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction
(Frontiers Media S.A., 2020-06)
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies ...
Immunogenicity to biological drugs in psoriasis and psoriatic arthritis
(Hospital Clinicas, Brasil, 2021)
Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological ...
Foxp3 silencing with antisense oligonucleotide improves immunogenicity of an adjuvanted recombinant vaccine against sporothrix schenckii
(2021-04-01)
Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells ...
Dendritic Cells and Immunogenic Cancer Cell Death: A Combination for Improving Antitumor Immunity
(MDPI, 2020-03)
The safety and feasibility of dendritic cell (DC)-based immunotherapies in cancer management have been well documented after more than twenty-five years of experimentation, and, by now, undeniably accepted. On the other ...
Effect of repetitiveness on the immunogenicity and antigenicity of Trypanosoma cruzi FRA protein
(Academic Press Inc Elsevier Science, 2011-03)
Repetitive proteins (RP) of Trypanosoma cruzi are highly present in the parasite and are strongly recognized by sera from Chagas' disease patients. Flagelar Repetitive Antigen (FRA), which is expressed in all steps of the ...
BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade
(Nature Publishing Group, 2021-12)
Bromodomain and Extra-Terminal domain (BET) family proteins are epigenetic readers thatplay a critical role in oncogenesis by controlling the expression of oncogenes such as c-Myc.Targeting BET family proteins has recently ...
Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
(Universidad del Rosario, 2010)
Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic ...
Immunogenicity in Protein and Peptide Based-Therapeutics: An OverviewInmunogenicidad en terapias basadas en proteínas y péptidos: descripción general
(Current Protein and Peptide Science, 2018)
Currently it is well known that all biological drugs, including those with a fully human structure, are capable of inducing a host immune response known as immunogenicity [1]. The presence of ADAs can condition the drug´s ...