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Severe changes in thymic microenvironment in a chronic experimental model of paracoccidioidomycosis
(2016-10-01)
T cell maturation takes place within the thymus, a primary lymphoid organ that is commonly targeted during infections. Previous studies showed that acute infection with Paracoccidioides brasiliensis (Pb), the causative ...
CCR5-Dependent Homing of T Regulatory Cells to the Tumor Microenvironment Contributes to Skin Squamous Cell Carcinoma Development
(Amer Assoc Cancer Research, 2017-12-01)
Squamous cell carcinoma (SCC) is one of the most common human cancers worldwide. Recent studies show that regulatory T cells (Treg) have a critical role in the modulation of an antitumor immune response, and consequently ...
Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma
(WILEY-BLACKWELLHOBOKEN, 2012)
Objective Immune responses against differentiated thyroid carcinomas (DTC) have long been recognized. We aimed to investigate the role of immune cell infiltration in the progression of DTC. Design We studied 398 patients ...
Mathematical modelling of microtumour infiltration based on in vitro experiments
(Royal Society of Chemistry, 2016-08-08)
The present mathematical models of microtumours consider, in general, volumetric growth and spherical tumour invasion shapes. Nevertheless in many cases, such as in gliomas, a need for more accurate delineation of tumour ...
Immunosuppressive Myeloid Cells’ Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy
(Nature Publishing Group, 2017-01)
Survival of glioma (GBM) patients treated with the current standard of care remains dismal. Immunotherapeutic approaches that harness the cytotoxic and memory potential of the host immune system have shown great benefit ...
Microenvironmental influence on microtumour infiltration patterns: 3D-mathematical modelling supported by: In vitro studies
(Royal Society of Chemistry, 2018-05)
Mathematical modelling approaches have become increasingly abundant in cancer research. Tumour infiltration extent and its spatial organization depend both on the tumour type and stage and on the bio-physicochemical ...
Chronic Hepatitis C Pathogenesis: Immune Response in the Liver Microenvironment and Peripheral Compartment
(Frontiers Media, 2021-08)
Chronic hepatitis C (CHC) pathogenic mechanisms as well as the participation of the immune response in the generation of liver damage are still a topic of interest. Here, we evaluated immune cell populations and cytokines ...
Severe Changes In Thymic Microenvironment In A Chronic Experimental Model Of Paracoccidioidomycosis
(Public Library ScienceSan Francisco, 2016)
The relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer
(NLM (Medline), 2018)
A complex network of chemokines can influence cancer progression with the recruitment and activation of hematopoietic cells, including macrophages to the supporting tumor stroma promoting carcinogenesis and metastasis. The ...