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Epiregulin (EREG) is upregulated through an IL-1β autocrine loop in Caco-2 epithelial cells with reduced CFTR function
(Wiley, 2018)
Abstract: CFTR is a cAMP-regulated chloride channel, whose mutations produce cystic fibrosis. The impairment of CFTR activity increases the intracellular Cl- concentration, which in turn produces an increased interleukin-1β ...
Interleukin-1β regulates CFTR expression in human intestinal T84 cells
(Elsevier Science, 2000-02)
Cystic fibrosis is an autosomal recessive genetic disease, produced by a mutation in the CFTR gene that impairs its function as a chloride channel. In this work, we have examined the effects of interleukin-1β (IL-1β) on ...
Interaction of epigallocatechin-gallate and chlorhexidine with Streptococcus mutans stimulated odontoblast-like cells: Cytotoxicity, Interleukin-1β and co-species proteomic analyses
(2021-11-01)
Objectives: The dentin therapeutic agent chlorhexidine has inflammatory and cytotoxic characteristics urging investigation of alternatives like the natural compound epigallocatechin-gallate. The aim is to verify the effect ...
Crude leaf extracts of piperaceae species downmodulate inflammatory responses by human monocytes
(2018-06-01)
In this study, we aimed to evaluate the immunomodulatory effects of crude leaf extracts from Piper gaudichaudianum Kunth, P. arboreum Aub., P. umbellata L., P. fuligineum Kunth, and Peperomia obtusifolia A. Dietr. on an ...
Papel de tgf-β1 en macrófagos infectados con virus dengue
(El autor, 2018)
CNS response to a second pro-inflammatory event depends on whether the primary demyelinating lesion is active or resolved
(Academic Press Inc Elsevier Science, 2012-07)
Interleukin-1β (IL-1β) is considered to be one of the most important mediators in the pathogenesis of inflammatory diseases, particularly in neurodegenerative diseases such as multiple sclerosis (MS). MS is a chronic ...
A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina
(Liga Brasileira de Epilepsia (LBE), 2010-09-01)
INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. ...
Efeitos dos betas-bloqueadores na sepse em camundongos
(Universidade Estadual Paulista (Unesp), 2020-05-15)
Introdução: Sepse é uma das mais antigas síndromes reconhecidas na história da medicina. Atualmente, é descrita como uma resposta inflamatória sistêmica desregulada do hospedeiro à infecção que ocasiona diversos comprometimentos ...