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Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies
(Karger, 2017)
Background: The growth-promoting effects of IGF-I is mediated through the IGF-I receptor (IGF1R), a widely expressed cell-surface tyrosine kinase receptor. IGF1R copy number variants (CNV) can cause pre- and postnatal ...
The Motor KIF5C Links the Requirements of Stable Microtubules and IGF-1 Receptor Membrane Insertion for Neuronal Polarization
(Springer, 2017-10-03)
Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of ...
Estudio in silico de la interacción entre la insulina glargina y los receptores IR e IGF1R
(2016-12-14)
Introducción: La glargina es un análogo de la insulina utilizado para el tratamiento de la diabetes mellitus. Se ha reportado que este análogo presenta actividad mitogénica y que podría tener relación con cáncer en algunos ...
Miostatina inhibe la vía de señalización IGF-1/PI3K/PLCγ/NFATc3 a través del receptor Activina tipo IB (ActRIB)
(Universidad Andrés Bello, 2017)
Miostatina, un miembro de la familia TGF-β, es una proteína expresada principalmente en el músculo esquelético que cumple un rol inhibidor en la proliferación y diferenciación de células musculares. Miostatina ejerce su ...
New insights into IGF-1 signaling in the heart
(Elsevier, 2014)
Insulin-like growth factor 1 (IGF-1) signaling regulates
contractility, metabolism, hypertrophy, autophagy,
senescence, and apoptosis in the heart. IGF-1 deficiency
is associated with an increased risk of cardiovascul ...
A putative mechanism of age-related synaptic dysfunction based on the impact of IGF-1 receptor signaling on synaptic CaMKIIα phosphorylation
(Frontiers Research Foundation, 2018-05)
Insulin-like growth factor 1 receptor (IGF-1R) signaling regulates the activity and phosphorylation of downstream kinases linked to inflammation, neurodevelopment, aging and synaptic function. In addition to the control ...
Differential expression of members of the IGF system in OPU-derived oocytes from Nelore (Bos indicus) and Holstein (Bos taurus) cows
(2013-05-01)
The insulin-like growth factor (IGF) system is related to quality of oocytes and embryos. The aim of this study was to investigate the mRNA levels of IGF1 and IGF2 and their receptors, IGFR1 and IGFR2, as well as IGFBP2, ...
Differential expression of members of the IGF system in OPU-derived oocytes from Nelore (Bos indicus) and Holstein (Bos taurus) cows
(2013-05-01)
The insulin-like growth factor (IGF) system is related to quality of oocytes and embryos. The aim of this study was to investigate the mRNA levels of IGF1 and IGF2 and their receptors, IGFR1 and IGFR2, as well as IGFBP2, ...
Woodhouse-Sakati syndrome: a case reportSíndrome de Woodhouse Sakati
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana, 2008)