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Heme-Oxygenase-1
(Mary Ann Liebert, 2020-04-30)
This Forum issue “Heme Oxygenase” (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving ...
The effect of nitric oxide on Heme Oxygenase gene expression in soybean leaves
(Springer, 2007-10)
Heme oxygenase (HO, EC 1.14.99.3) catalyzes the oxidative conversion of heme to biliverdin IXalpha with the concomitant release of carbon monoxide and iron. Recently, HO has been involved in the protection against oxidative ...
Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes
(American Society for Biochemistry and Molecular Biology, 2004-10)
Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex ...
Involvement of the heme oxygenase-carbon monoxide-cGMP pathway in the nociception induced by acute painful stimulus in rats
(ELSEVIER SCIENCE BV, 2011)
Heme oxygenase-carbon monoxide-cGMP (HO-CO-cGMP) pathway has been reported to be involved in peripheral and spinal modulation of inflammatory pain. However, the involvement of this pathway in the modulation of acute painful ...
Expression of heme oxygenase-1 in non small cell lung cancer (NSCLC) and its correlation with clinical data
(Elsevier Ireland, 2012-07)
While changes in heme oxygenase (HO-1) in lung cancer have already been reported, conflicting results were obtained for enzyme expression in human lung cancer specimens. Therefore, the aim of this work was to study HO-1 ...
Nitric oxide synthase-like dependent NO production enhances heme oxygenase up-regulation in ultraviolet-B-irradiated soybean plants
(Elsevier, 2010-10)
Heme oxygenase (HO) has antioxidant properties and is up-regulated by reactive oxygen species (ROS) in ultraviolet-B-irradiated soybean plants. This study shows that nitric oxide (NO) protects against oxidative damage and ...
Nuclear localization of heme oxygenase-1 in pathophysiological conditions: Does it explain the dual role in cancer?
(Multidisciplinary Digital Publishing Institute, 2021-01)
Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin. HO-1 was ...
Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
(Wiley Blackwell Publishing, Inc, 2006-12)
1. Addition of fructose to a rat diet for various time periods leads to hypertension, hyperinsulinemia and dyslipidemia and provides a model for testing oxidative stress parameters in the animals. 2. The oxidative stress ...
Heme oxygenase-1 has antitumoral effects in colorectal cancer: Involvement of p53
(Elsevier, 2014-09)
The expression of heme oxygenase-1 (HO-1) has been shown to be up-regulated in colorectal cancer (CRC), but the role it plays in this cancer type has not yet been addressed. The aims of this study have been to analyze HO-1 ...