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Cyclophilin-A is bound to through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex
(American Society for Biochemistry and Molecular Biology, 2004-10-20)
Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known. ...
Management of cytoskeleton architecture by molecular chaperones and immunophilins
(Elsevier Science Inc, 2011-12)
Cytoskeletal structure is continually remodeled to accommodate normal cell growth and to respond to pathophysiological cues. As a consequence, several cytoskeleton-interacting proteins become involved in a variety of ...
TPR-Domain immunophilin FKBP51 is a major mitochondrial protein that protects cells against oxidative stress
(American Society For Biochemistry And Molecular Biology, 2011-07-05)
Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker MitoTracker. Signal specificity was tested with ...
Dynamic mitochondrial–nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation
(Company of Biologists, 2013-12)
Glucocorticoids play an important role in adipogenesis via the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high molecular weight immunophilin FKBP51 or FKBP52. When 3T3-L1 preadipocytes ...
La redistribución dinámica mitocondria-núcleo de la inmunofilina fkbp51 es regulada por pka para modular la expresión de genes durante el proceso de adipogénesisThe dynamic mitochondria-nuclear redistribution of FKBP51 during the process of adipocyte differentiation is regulated by PKA
(Medicina (Buenos Aires), 2013-11)
Los glucocorticoides tienen un papel central en la adipogénesis, por su unión al receptor RG cito-plasmático formando parte de un heterocomplejo también integrado por una inmunofilina (INM) de alto peso molecular, FKBP51 ...