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Inhibition and activation of UDP-glucuronyltransferase in alloxanic-diabetic rats
(1986)
Short or long term alloxan diabetes produced activation of oestrone and morphine glucuronidation and inhibition of p-nitrophenol glucuronidation in rat liver microsomes. Insulin treatment restored decreased glucuronyltransferase ...
Route of metabolization and detoxication of paralytic shellfish toxins in humans
(ELSEVIER, 2010)
Paralytic shellfish toxins (PST) are a collection of over 26 structurally related imidazoline
guanidinium derivatives produced by marine dinoflagellates and freshwater cyanobacteria.
Glucuronidation of drugs by ...
Evidence of in vitro glucuronidation and enzymatic transformation of paralytic shellfish toxins by healthy human liver microsomes fractionTOXICONTOXICON
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Hepatic bile formation: Canalicular osmolarity and paracellular and transcellular water flow
(American Society for Pharmacology and Experimental Therapeutics, 2019-12)
The purpose of this minireview is to show that a new paradigm is developing regarding hepatic bile flow. The focus thus far has been on carrier-mediated transport of bile acids and other solutes, such as glutathione, which ...
Nucleotide activation of liver microsomal glucuronidation
(American Society for Biochemistry and Molecular Biology, 1961-02)
Prevention of estradiol 17β-d-glucuronide– induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes
(American Society for Cell Biology, 2011-08)
In estradiol 17β-d-glucuronide (E17G)–induced cholestasis, the canalicular hepatocellular transporters bile salt export pump (Abcb11) and multidrug-resistance associated protein 2 (Abcc2) undergo endocytic internalization. ...
Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy
(Elsevier B.V., 1997)
Background/Aims and Methods: The mechanism(s) behind the effects of ursodeoxycholic acid on serum steroid sulphate profiles in patients with intrahepatic cholestasis of pregnancy is not clear. Conjugated progesterone ...
Diabetes in female rats; changes in liver microsomal aminopyrine N-demethylase and UDP-glucuronyl transferase activities
(1990)
Short or long term diabetes in female rats produced remarkable activation of aminopyrine N-demethylation, inhibition of oestrone and p-nitrophenol glucuronidation and no changes in morphine UDP-glucuronyltransferase activity ...