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Specific insulin and proinsulin secretion in glucokinase-deficient individuals
(Associação Brasileira de Divulgação Científica, 1999-04-01)
Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young ...
Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior
(Nature Publishing Group, 2017-06-16)
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several ...
Specificity evolution of the ADP-dependent sugar kinase family: in silico studies of the glucokinase/phosphofructokinase bifunctional enzyme from Methanocaldococcus jannaschii.
(Federation of European Biochemical Societies, Blackwell Publishing Ltd, 2008-07-10)
In several archaea of the Euryarchaeota, the glycolytic flux proceeds through a modified version of the Embden-Meyerhof pathway, where the phosphofructokinase and glucokinase enzymes use ADP as the phosphoryl donor. These ...
Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes
(PUBLIC LIBRAY OF SCIENCE, 2014)