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Urotensin II: Molecular mechanisms of biological activity
(Bentham Science Publishers B.V., 2018)
Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases
(American Society for Pharmacology and Experimental Therapeutics, 2001-11)
The histamine H2 receptor (H2r) belongs to the heptahelical receptor family; upon agonist binding, members of this family activate a G protein and the downstream effector adenylyl cyclase. Like other G protein-coupled ...
Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012)
Objectives: To investigate the role of toll-like receptor 9 on sepsis-induced failure of neutrophil recruitment to the site of infection. Design: Prospective experimental study. Setting: University research laboratory. ...
Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models
(Royal Society of Chemistry, 2015-07)
With >800 members in humans, the G protein-coupled receptor (GPCR) super-family is the target for more than 30% of the marketed drugs. The recent boom in GPCR crystallography has enabled the solution of ∼30 different GPCR ...
G protein coupled receptors and their desensitization
(Facultad de Odontología, 2011)
Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins
(ELSEVIER SCIENCE BV, 2008)
In the kallikrein-kinin and renin-angiotensin systems the main receptors, B-1 and B-2 (kinin receptors) and AT(1) and AT(2) (angiotensin receptors) respectively, are seven-transmembrane domain G-protein-coupled receptors. ...
The Visual Cycle in the Inner Retina of Chicken and the Involvement of Retinal G-Protein-Coupled Receptor (RGR)
(Springer, 2017-05-17)
The vertebrate retina contains typical photoreceptor (PR) cones and rods responsible for day/night vision, respectively, and intrinsically photosensitive retinal ganglion cells (ipRGCs) involved in the regulation of ...
Angiotensin-(1-7) and the g protein-coupled receptor mas are key players in renal inflammation
(PUBLIC LIBRAY OF SCIENCE, 2009)