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Caracterização de inibidores da coagulação sanguínea e da agregação plaquetária presentes na saliva do carrapato Amblyomma cajennense (Acari: Ixodidae) (Fabricius, 1787)
(Universidade Federal de São Paulo (UNIFESP), 2003)
Os carrapatos constituem um dos mais importantes grupos de artropode parasitas hematofagos de animais domesticos, silvestres e do homem. 0 Amblyomma cajennese constitui uma das principais especies de vetores de varios ...
Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein
(American Heart AssociationDallas, 2013-06)
BACKGROUND:
Generation of active procoagulant cofactor factor Va (FVa) and its subsequent association with the enzyme activated factor X (FXa) to form the prothrombinase complex is a pivotal initial event in blood coagulation ...
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
(Springer, 2016)
During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to ...
Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background: The expression levels of the clotting initiator protein Tissue Factor (TF) correlate with vessel density and the histological malignancy grade of glioma patients. Increased procoagulant tonus in high grade ...
Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its ...
Monitorização e manejo de pacientes em uso de novos anticoagulantes orais no contexto da emergência
(Florianópolis, SC, 2021)
Activation of platelet tissue factor is mediated by GPIba signailing with final activation of AKT
(2016)
Human platelets express tissue factor mRNA, synthesize the protein and store functionally silent
tissue factor (TF) which has procoagulant activity (PCA) after platelet activation. Platelet GPIbα plays
a major role in ...
Ação de proteínas isoladas de plantas na hemostasia e trombose
(Universidade Federal de São Paulo (UNIFESP), 2017-06-29)
Protein from plants may act as inhibitors and thus used to assess blood coagulation, thrombosis and inflammation, in order. to determine the role of certain coagulation enzymes in hemostasis. Such inhibitors may be considered ...
Solvent Free Efficient Synthesis of New 4-thiazolidinones with Fructose Scaffold through a Microwave Assisted Cascade Multicomponent Reaction
(2023)
Using a chemoselective, sustainable and highly efficient method, new 4-thiazolidinones and 1,4-thiazepan-3-ones substituted by a glycosidic residue derived from D-fructose were synthesized. Microwave-assisted cascade ...