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Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice
(American Society for Biochemistry and Molecular Biology, 2013-09)
Reporter mice that enable the activity of the endogenous p21 promoter to be dynamically monitored in real time in vivo and under a variety of experimental conditions revealed ubiquitous p21 expression in mouse organs ...
Antiproliferative effects of Bortezomib in endothelial cells transformed by viral G protein-coupled receptor associated to Kaposi's sarcoma
(Elsevier Science Inc, 2017-04)
The Kaposi's Sarcoma-associated Herpes virus G Protein-Coupled Receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi Sarcoma. We have previously demonstrated that the proteasome inhibitor Bortezomib inhibits ...
Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators
(IRCA-BSSA, 2017)
Fibroblasts play several homeostatic roles, including electrical coupling, paracrine signaling and tissue repair after injury. Fibroblasts have low secretory activity. However, in response to injury, they differentiate to ...
Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats
(Sage Publications Ltd, 2015-06-01)
Aim: To investigate whether lycopene can modulate adiponectin levels and SIRT1 and FoxO1 gene expression in the adipose tissue of diet-induced obese rats.Methods: Male Wistar rats were first fed with hypercaloric diet (HD, ...
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
(2013-06-14)
Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle. However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 ...
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
(2013-06-14)
Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle. However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 ...
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
(AMER SOC CLINICAL INVESTIGATION INC, 2012-03)
The leading cause of death in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and function, independent of hypertension or coronary disease. However, ...
Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells
(Cell Press, 2020-03)
MAPK phosphatases (MKP) downregulate the activity of mitogen-activated protein kinases (MAPK), such asERK1/2, and modulate the processes regulated by these kinases. ERK1/2 participate in a wide range of processesincluding ...
Fator foxo e sinalização nutricional na reprodução de Blatella germânica
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Genética e BioquímicaCiências BiológicasUFU, 2016)
17β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families
(Wiley-liss, Div John Wiley & Sons Inc, 2017-01-01)
17β-Estradiol (E2) protects several nonreproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2O2 in skeletal myoblasts, ...