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The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress
(American Society for Biochemistry and Molecular Biology, 2011-08)
Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker Mito-Tracker. Signal specificity was tested with ...
SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress
(Elsevier Science Inc, 2019-11)
In order to adequately respond to stressful stimuli, glucocorticoids (GCs) target almost every tissue of the body. By exerting a negative feedback loop in the hypothalamic–pituitary–adrenal (HPA) axis GCs inhibit their own ...
Subcellular rearrangement of Hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth
(Wiley, 2010-11)
FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors. Immunophilins are ...
The emerging role of TPR-domain immunophilins in the mechanism of action of action of steroid receptors
(AgiAL Publishing Group, 2014-11-30)
In the absence of ligand, some members of nuclear receptor family such as corticosteroid receptors are primarily located in the cytoplasm, and they rapidly accumulate in the nucleus upon ligand-binding. Other members of ...
Role of mitochondrial heat-shock proteins and immunophilins in neurodegenerative diseases
(Bentham Science Publishers, 2021)
Pathophysiologic conditions of neurodegenerative diseases are unquestionably related to protein misfolding. The accumulation of misfolded proteins into relatively ordered structures such as fibrillar intracellular and ...
Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
(Agial Publishing House, 2014-10-05)
It is well known that glucocorticoids and mineralocorticoids are part of the list of hormones that control adipogenesis as well as different aspects of the physiology of the adipose tissue. Their actions are mediated through ...
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
(Wiley Blackwell Publishing, Inc, 2012-07)
Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are ...
Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
(Frontiers Research Foundation, 2018-05)
Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor ...
Regulation of NF-kB signalling cascade by immunophilins
(Bentham Science Publishers, 2016-01)
The fine regulation of signalling cascades is a key event required to maintain the appropriate functional properties of a cell when a given stimulus triggers specific biological responses. In this sense, cumulative ...
Differential Recruitment of Tetratricorpeptide Repeat Domain Immunophilins to the Mineralocorticoid Receptor Influences both Heat-Shock Protein 90-Dependent Retrotransport and Hormone-Dependent Transcriptional Activity
(American Chemical Society, 2007-11)
The mineralocorticoid receptor (MR) forms oligomers with the heat-shock protein 90 (Hsp90) -based heterocomplex, which contains tetratricopeptide repeat (TPR) domain immunophilins (IMMs). Here we investigated the unknown ...