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Melatonin decreases estrogen receptor binding to estrogen response elements sites on the oct4 gene in human breast cancer stem cells
(2016-05-01)
Cancer stem cells (CSCs) pose a challenge in cancer treatment, as these cells can drive tumor growth and are resistant to chemotherapy. Melatonin exerts its oncostatic effects through the estrogen receptor (ER) pathway in ...
The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration : Beneficial or Harmful?
(2021-03-08)
Estrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of estrogen receptors, while the G protein-coupled ...
Primordial germ cells (spermatogonial stem cells) of bullfrogs express sex hormone-binding globulin and steroid receptors during seasonal spermatogenesis
(2013-01-01)
In vertebrate species, testosterone seems to inhibit spermatogonial differentiation and proliferation. However, this androgen can also be converted, via aromatase, into estrogen which stimulates spermatogonial differentiation ...
Primordial germ cells (spermatogonial stem cells) of bullfrogs express sex hormone-binding globulin and steroid receptors during seasonal spermatogenesis
(2013-01-01)
In vertebrate species, testosterone seems to inhibit spermatogonial differentiation and proliferation. However, this androgen can also be converted, via aromatase, into estrogen which stimulates spermatogonial differentiation ...
Effects of 17 beta-estradiol on expression of muscarinic acetylcholine receptor subtypes and estrogen receptor alpha in rat hippocampus
(Elsevier B.V., 2010-05-25)
The aim of the present study was to investigate the effects of 17 beta-estradiol on expression of muscarinic acetylcholine receptor subtypes (M(1) to M(5)) and estrogen receptor alpha, in the rat hippocampus. Hippocampi ...
The subcellular localization and physiological roles of estrogen receptors α and β in classical and non-classical tissues
(Nova Science Publishers, 2017)
It is now firmly established that estrogens elicit a variety of rapid effects in many tissues in addition to their delayed action on gene expression in the cell nucleus. Moreover, the classic estrogen receptors have been ...