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p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled
(American Society for Microbiology, 2006-12)
We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21(WAF1/CIP1). Here, we investigated the ...
Postnatal ontogeny and the evolution of macrostomy in snakes
(Royal Society, 2016-11-09)
Macrostomy is the anatomical feature present in macrostomatan snakes that permits the ingestion of entire prey with high cross-sectional area. It depends on several anatomical traits in the skeleton and soft tissues, of ...
Ossificação do complexo estilohióide em uma população com disfunção temporomandibular: um estudo caso controle
(Universidade Federal de Minas GeraisUFMG, 2009-08-13)
The styloid process arises from the tympanic part of the temporal bone and he is considered elongated if it has 30 mm in length or longer. Many of the symptons associated with an elongated styloid process, such as pain in ...
Auxin and Cellular Elongation
(American Society Of Plant Biologist, 2016-03)
Auxin is a crucial growth regulator in plants. However, a comprehensive understanding of how auxin induces cell expansion is perplexing, because auxin acts in a concentration- and cell type-dependent manner. Consequently, ...
Understanding the ion-induced elongation of silver nanoparticles embedded in silica
(Nature Publishing Group, 2017-12)
In this work we have studied the elongation of silver nanoparticles irradiated with 40 MeV Bromine ions by means of in situ optical measurements, transmission electron microscopy and molecular dynamics simulations. The ...
Contrasting roles of the RSC and ISW1/CHD1 chromatin remodelers in RNA polymerase II elongation and termination
(Cold Spring Harbor Laboratory Press, 2019-03)
Most yeast genes have a nucleosome-depleted region (NDR) at the promoter and an array of regularly spaced nucleosomes phased relative to the transcription start site. We have examined the interplay between RSC (a conserved ...
Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis
(2016-10-01)
The translation elongation factor eIF5A is conserved through evolution and is necessary to rescue the ribosome during translation elongation of polyproline-containing proteins. Although the site of eIF5A binding to the ...
Lipidome signatures in early bovine embryo development
(Elsevier B.V., 2016-07-15)
Mammalian preimplantation embryonic development is a complex, conserved, and well orchestrated process involving dynamic molecular and structural changes. Understanding membrane lipid profile fluctuation during this crucial ...
Perception and signalling of light and temperature cues in plants
(Wiley Blackwell Publishing, Inc, 2017-05-23)
Light and temperature patterns are often correlated under natural plant growth conditions. In this review, we analyse the perception and signalling mechanisms shared by both these environmental cues and discuss the functional ...