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Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner
(SOC NEUROSCIENCE, 2010)
Although the anti-inflammatory actions of glucocorticoids (GCs) are well established, evidence has accumulated showing that proinflammatory GC effects can occur in the brain, in a poorly understood manner. Using electrophoretic ...
Eye enucleation activates the transcription nuclear factor kappa-B in the rat superior colliculus
(ELSEVIER IRELAND LTDCLARE, 2012)
Ocular enucleation produces significant morphological and physiological changes in central visual areas. However, our knowledge of the molecular events resulting from eye enucleation in visual brain areas remains elusive. ...
Lymphoid B cells induce NF-κB activation in high endothelial cells from human tonsils
(2006)
Immune surveillance depends on still poorly understood lymphocyte-endothelium interactions required for lymphocyte transendothelial migration into secondary lymphoid organs. The nuclear factor κB (NF-κB) regulatory system ...
Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis
(American Association for Cancer Research (AACR), 2007-11-01)
Animal and cell studies indicate an inhibitory effect of matrix metalloproteinase-8 (MMP8) on tumorigenesis and metastasis. We investigated whether MMP8 gene variation was associated with breast cancer metastasis and ...
A Genome-wide Screen for Neurospora crassa Transcription Factors Regulating Glycogen Metabolism
(Amer Soc Biochemistry Molecular Biology Inc, 2011-11-01)
Transcription factors play a key role in transcription regulation as they recognize and directly bind to defined sites in promoter regions of target genes, and thus modulate differential expression. The overall process is ...
Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis
(American Association for Cancer Research (AACR), 2007-11-01)
Animal and cell studies indicate an inhibitory effect of matrix metalloproteinase-8 (MMP8) on tumorigenesis and metastasis. We investigated whether MMP8 gene variation was associated with breast cancer metastasis and ...
The ferric iron uptake regulator (Fur) from the extreme acidophile Acidithiobacillus ferrooxidans
(SOC GENERAL MICROBIOLOGY, 2005-06)
Acidithiobacillus ferrooxidans is a Gram-negative bacterium that lives at pH 2 in high concentrations of soluble ferrous and ferric iron, making it an interesting model for understanding the biological mechanisms of bacterial ...
Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid
(Springer Nature, 2020)
Pyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment regimens. Approximately 50% of multidrug-resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are ...
Andrographolide interferes with binding of nuclear factor-kb to dna in hl-60-derived neutrophilic cells
(WILEY-BLACKWELL, 2005)
1 Andrographolide, the major active component from Andrographis paniculata, has shown to possess anti-inflammatory activity. Andrographolide inhibits the expression of several proinflammatory proteins that exhibit a nuclear ...
Abnormality of Oct-1 DNA binding in T cells from Sjogren's syndrome patients
Primary Sjögren's syndrome (SS) is an autoimmune rheumatic disease characterized by T cell hypoactivity. To understand the diminished T cell response to activation signals, we measured nucleoprotein DNA?binding activities ...