Buscar
Mostrando ítems 21-30 de 7048
Tailored Multi-Target Agents: Applications and Design Considerations
(Bentham Science Publishers, 2016-03)
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...
Artificial Itelligence Teaches Drugs to Target Proteins by Tackling the Induced Folding Problem
(American Chemical Society, 2020-06-17)
We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...
Prediction of drug targets in human pathogens
(Universidade Federal de Minas GeraisUFMG, 2017-02-21)
The rapid emergence of resistant bacteria makes today's antibiotics more and more ineffective, consequently increasing the need for new pharmacological targets and novel classes of antibacterial drugs. The identification ...
POTENTIAL MOLECULAR TARGETS FOR ANTITUBERCULOSIS DRUG DISCOVERY
(Soc Brasileira Quimica, 2017-06-01)
Tuberculosis (TB) is an infectious disease caused by mycobacteria from the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) aims to reduce the number of TB cases worldwide ...
Network pharmacology and epilepsy
(Springer, 2016)
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...
Advanced Modeling Reconciles Counterintuitive Decisions in Lead Optimization
(Elsevier Science London, 2017-06)
Lead optimization (LO) is essential to fulfill the efficacy and safety requirements of drug-based targeted therapy. The ease with which water may be locally removed from around the target protein crucially influences LO ...
Shikimate kinase: A potential target for development of novel antitubercular agents
(Bentham Science Publ Ltd, 2007-03-01)
Tuberculosis (TB) remains the leading cause of mortality due to a bacterial pathogen, Mycobacterium tuberculosis. However, no new classes of drugs for TB have been developed in the past 30 years. Therefore there is an ...
Electrical Currents from Diffusion Equation and Electrodynamics at Targeted Drug Delivery Strategies
(Institute of Electrical and Electronics EngineersPE, 2021-10-22)
This paper presents a theoretical approach of a prospective scheme inside Nanomedicine known as Targeted Drug Delivery (TDD) based entirely on Classical Electrodynamics. Under the assumption that nanoparticles can be ...
Hybrid compounds as anti-infective agents
(Bentham Science Publishers, 2017-04)
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution ...