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Drug discovery: Insights from the invertebrate Caenorhabditis elegans
(John Wiley & Sons Ltd, 2021-04-09)
Therapeutic drug development is a long, expensive, and complex process that usually takes 12–15 years. In the early phases of drug discovery, in particular, there is a growing need for animal models that ensure the reduction ...
The cost-effectiveness of 10 antenatal syphilis screening and treatment approaches in Peru, Tanzania, and Zambia
(Wiley, 2015)
OBJECTIVE: Rapid plasma reagin (RPR) is frequently used to test women for maternal syphilis. Rapid syphilis immunochromatographic strip tests detecting only Treponema pallidum antibodies (single RSTs) or both treponemal ...
Structure-based drug design strategies in medicinal chemistry
(Bentham ScienceSharjah, 2009-06)
A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of
leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design ...
Integração das técnicas de triagem virtual e triagem biológica automatizada em alta escala: oportunidades e desafios em P&D de fármacos
(Sociedade Brasileira de Química - SBQSão Paulo, 2011)
High-throughput screening (HTS) and virtual screening (VS) are useful methods employed in drug discovery, allowing the identification of promising hits for lead optimization. The efficiency of these approaches depends on ...
Past and future of trypanosomatids high-throughput phenotypic screening
(Fiocruz/IOC, 2022)
Treatment of fibrinolytic alveolitis with rifamycin B diethylamide associated with gelfoam: a histological study.
(1997-12-01)
The most common complication in the healing of extraction wounds is fibrinolytic alveolitis, which may also be termed dry socket. Reduction in the incidence of this condition after the application of topical antibiotics ...
Treatment of fibrinolytic alveolitis with rifamycin B diethylamide associated with gelfoam: a histological study.
(1997-12-01)
The most common complication in the healing of extraction wounds is fibrinolytic alveolitis, which may also be termed dry socket. Reduction in the incidence of this condition after the application of topical antibiotics ...