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Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats
(BioScientifica, 2013-09)
Mammary stroma is composed of various cell types, including migratory leukocytes. Although mammary antibody-secreting cells have been extensively studied, reports focusing on mammary T cells are scarce. It is thought that ...
Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity
(2019-12-01)
Exfoliative toxins (ETs) are secreted virulence factors produced by staphylococci. These serine proteases specifically cleave desmoglein 1 (Dsg1) in mammals and are key elements in staphylococcal skin infections. We recently ...
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil
(Elsevier B.V., 2017-12-01)
Background: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF ...
Staphylococcus aureus Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism
(Mdpi, 2022-09-01)
Staphylococcal exfoliative toxins (ETs) are glutamyl endopeptidases that specifically cleave the Glu381-Gly382 bond in the ectodomains of desmoglein 1 (Dsg1) via complex action mechanisms. To date, four ETs have been ...
Profile of Trypanosoma cruzi Reactivity in a Population at High Risk for Endemic Pemphigus Foliaceus (Fogo Selvagem)
(AMER SOC TROP MED & HYGIENEMCLEAN, 2012-10)
Fogo Selvagem (FS) is an autoimmune bullous disease with pathogenic IgG autoantibodies recognizing desmoglein 1 (Dsg1), a desmosomal glycoprotein. In certain settlements of Brazil, a high prevalence of FS (3%) is reported, ...
Estudo clínico e epidemiológico dos casos de pênfigo foliáceo endêmico e pênfigo vulgar em um centro de referência no estado de Minas Gerais, Brasil
(Universidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE CLÍNICA MÉDICAPrograma de Pós-Graduação em Ciências Aplicadas à Saúde do AdultoUFMG, 2022-09-15)
Background: pemphigus is a group of bullous autoimmune diseases. The most common of which are pemphigus vulgaris and pemphigus foliaceus, the latter predominating in Brazil in the endemic form, also known as “fogo selvagem”. ...
Elastic versus brittle mechanical responses predicted for dimeric cadherin complexes
(2022-03-15)
Cadherins are a superfamily of adhesion proteins involved in a variety of biological processes that include the formation of intercellular contacts, the maintenance of tissue integrity, and the development of neuronal ...
Collective mechanical responses of cadherin-based adhesive junctions as predicted by simulations
(2022-03-15)
Cadherin-based adherens junctions and desmosomes help stabilize cell-cell contacts with additional function in mechano-signaling, while clustered protocadherin junctions are responsible for directing neuronal circuits ...
Mupirocin Pemphigus-Like Drug Reaction in a Dog
(Universidade Federal do Rio Grande do Sul, 2019)
Avaliação do potencial cicatricial de formulações tópicas contendo beta-cariofileno em lesões cutâneas de ratos
(Universidade Estadual Paulista (Unesp), 2021-08-27)
A pele é fundamental para manter a integridade do organismo. A descontinuidade desse sistema promove o mecanismo cicatricial, que pode ser dividido em fases inflamatória, proliferativa e remodeladora. As lesões cutâneas ...