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Pannexin1 channels act downstream of p2x(7) receptors in atp-induced murine t-cell death
(LANDES BIOSCIENCE, 2014)
FasL-Triggered Death of Jurkat Cells Requires Caspase 8-Induced, ATP-Dependent Cross-Talk Between Fas and the Purinergic Receptor P2X7
(Wiley Periodicals, Inc., 2013)
Fas ligation via the ligand FasL activates the caspase-8/caspase-3-dependent extrinsic death pathway. In so-called type II cells, an additional
mechanism involving tBid-mediated caspase-9 activation is required to efficiently ...
Cimetidine-induced vascular cell apoptosis impairs testicular microvasculature in adult rats
(F Hernandez, 2012-10-01)
Cimetidine, an H-2 receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing ...
Soluble tumor necrosis factor alpha promotes retinal ganglion cell death in glaucoma via calcium-permeable ampa receptor activation
(Society for Neuroscience, 2015-09)
Loss of vision in glaucoma results from the selective death of retinal ganglion cells (RGCs). Tumor necrosis factorα (TNFα) signaling has been linked to RGC damage, however, the mechanism by which TNFα promotes neuronal ...
TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death
(Frontiers Media, 2020)
17 beta-estradiol is a neuronal survival factor against oxidative stress that triggers its protective effect even in the absence of classical estrogen receptors. The polymodal transient receptor potential vanilloid subtype ...
Disorders of apoptosis: Mechanisms for autoimmunity in primary immunodeficiency diseases
(SPRINGER/PLENUM PUBLISHERS, 2008)
A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain ...