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Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
(Future Science Group, 2020)
Arginine vasopressin controls p27(KiP1) protein expression by PKC activation and irreversibly inhibits the proliferation of K-Ras-dependent mouse Y1 adrenocortical malignant cells
(ELSEVIER SCIENCE BV, 2011)
The neurohypophyseal hormone arginine vasopressin (AVP) is a classic mitogen in many cells. In K-Ras-dependent mouse Y1 adrenocortical malignant cells, AVP elicits antagonistic responses such as the activation of the PKC ...
Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma
(BioMed Central, 2015)
Abstract
Background
Glioblastoma is the most common tumor of the central nervous system and one of the hardest tumors to treat. Consequently, the search for novel therapeutic ...
Atividade antiproliferativa e citotóxica do óleo essencial e extrato hidroalcóolico provenientes da Lippia grata SCHAUER
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA PARASITÁRIA, 2019-03-08)
The Caatinga is a rich biome with a flora well adapted to its predominant climate, the
semi-arid, where some of these plants have medicinal properties, among them the
Lippia grata (formerly Lippia gracilis), known as ...
Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells
(American Chemical Society, 2013)
Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of ...
Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
(Future Medicine, 2020-03)
Aim: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action.
Materials & methods: We describe in vitro studies ...
Mechanisms enhancing the cytotoxic effects of bleomycin plus suicide or interferon-β gene lipofection in metastatic human melanoma cells
(Bentham Science Publishers, 2018-05)
Background: Three metastatic human melanoma cell lines generated from patient removed lymph nodes and spleen metastasis were established in our laboratory. Objective: To investigate the mechanisms enhancing the cytotoxic ...
Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status
(Indian Acad Sciences, 2017-03-01)
Silibinin is a natural phenol found in the seeds of the milk thistle plant. Recent data have shown its effectiveness for preventing/treating bladder tumours. Therefore, in this study we investigated the cytotoxic and ...
The role of single cell derived vascular resident endothelial progenitor cells in the enhancement of vascularization in scaffold-based skin regeneration
(Elsevier, 2011)
Increasing evidence suggests that vascular resident endothelial progenitor cells (VR-EPCs) are present in
several organs, playing an important role in postnatal neovascularization. Here, we isolated and characterized
VR-EPCs ...
Aglycone flavonoid brachydin A shows selective cytotoxicity and antitumoral activity in human metastatic prostate (DU145) cancer cells
(2021-01-01)
In prostate cancer, flavonoids possess a wide variety of anticancer effects, focused on the antioxidant/pro-oxidant activity, inactivation of the androgen receptor, cell cycle arrest, apoptosis induction, metastasis ...