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Autocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukaemia
(Wiley Blackwell Publishing, Inc, 2005-07)
Chronic lymphocytic leukaemia (CLL) is characterized by the accumulation of long-lived B lymphocytes blocked in G(0/1) by impaired apoptosis. As insulin-like growth factor-I (IGF-I) is known for its antiapoptotic effects ...
SEPT10 expression in chronic lymphocytic leukemia. Correlation with clinical and biological prognostic factors
(Scientific Research, 2013-10)
Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. Microarray studies allowed highlight genes differentially expressed in this pathology. In this study, we have evaluated the prognostic ...
Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia
(Ferrata Storti Foundation, 2020-01)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal Bcellsin peripheral blood and lymphoid tissues 1. Circulating CLL cells are non-dividing Blymphocytes, but a significant fraction of the ...
Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies
(Pergamon-Elsevier B.V. Ltd, 2011-05-01)
Indole-3-acetic acid (IAA), when oxidized by horseradish peroxidase (HRP), is transformed into cytotoxic molecules capable of inducing cell injury. The aim of this study was to test if, by targeting hematopoietic tumors ...
Análise da expressão do marcador CD5 na leucemia linfocítica crônica de células B (LLC-B)
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicina, 2016-10-07)
The B cells chronic lymphocytic leukemia (B-CLL) is characterized by the abnormal proliferation of mature B lymphocytes, that can be observed in peripheral blood and bone marrow. Without any specific symptomatology, this ...
Smudge cells in peripheral blood smears did not differentiate chronic lymphocytic leukemia from other B-cell chronic lymphoprolipherative diseases
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2009)
Smudge cells has been classically associated with chronic lymphocytic leukemia (CLL), but they are found in peripheral blood tests for other chronic B-cell lymphoproliferative diseases (CLD). We investigated whether the ...