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From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
(Elsevier, 2016)
Abstract: Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their transmembrane (TM) region; ...
Ethanol's Action Mechanisms in the Brain: From Lipid General Alterations to Specific Protein Receptor Binding
(2017-02-23)
Ethanol is the most popular addictive substance used in the word. Its small and relatively simple structure facilitates its access to brain tissues and binding to many sites. This relatively unspecific action can partially ...
MUTAGENESIS AND TEMPERATURE-SENSITIVE LITTLE MACHINES
(INTECH, 2012)
In mammals a class of ion channels able to sense a wide range of temperatures (0-60 °C) has evolved. These molecular thermodynamic machines called thermo Transient Receptor Potential (thermoTRP) are spread through the ...
Structure-driven pharmacology of transient receptor potential channel vanilloid 1
(2016)
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a polymodal receptor that mediates the flux of cations across the membrane in response to several stimuli, including heat, voltage, and ligands. The best ...
Structure-driven pharmacology of transient receptor potential channel vanilloid 1
(2016)
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a polymodal receptor that mediates the flux of cations across the membrane in response to several stimuli, including heat, voltage, and ligands. The best ...
Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors
(Bentham Science Publishers, 2005-10)
The nicotinic acetylcholine receptor (AChR) is the archetype of the Cys-loop ligand-gated ion channel'receptor superfamily. Noncompetitive antagonists inhibit the AChR without interacting directly with agonist sites. Among ...
Voltage-controlled gating in a large conductance Ca2+-sensitive K+ channel (hslo)
(National Academy of Sciences, 1997)
Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels share properties of voltage-and ligand-gated ion channels. In voltage-gated channels, membrane depolarization promotes the displacement of charged residues ...