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Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas
(Associação Brasileira de Divulgação Científica, 2012)
The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding ...
Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection
(Associação Brasileira de Divulgação Científica, 2000-10)
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas ...
Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
(BioScientifica, 2012-09)
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human ...
Moderate exercise prevents functional remodeling of the anterior pituitary gland in diet-induced insulin resistance in rats: Role of oxidative stress and autophagy
(Endocrine Society, 2016-03)
A sustained elevation of glucocorticoid production, associated with the establishment of insulin resistance (IR) could addto the deleterious effects of the IR state. The aimofthis study is to analyze the consequences of ...
Folliculostellate cells in pituitary pars distalis of male viscacha: immunohistochemical, morphometric and ultrastructural study
(Società Italiana di Istochimica, 2010-01)
Folliculostellate ellate cells (FSC) have been reported in pituitary of several mammalian species. FSC morphology and secreted substances have been instrumental to the understanding of their function. The purpose of this ...
The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
(Karger, 2011-07)
Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as ...
Melatonin prevents early pituitary dysfunction induced by sucrose-rich diets
(Wiley Blackwell Publishing, Inc, 2019-03)
While physiological levels of glucocorticoids are required to ensure proper functions of the body, consistently high levels may engender several deleterious consequences. We have previously shown an increase in the activity ...
Strongyloides stercoralis hyperinfection syndrome presenting as severe, recurrent gastrointestinal bleeding, leading to a diagnosis of cushing disease
(American Society of Tropical Medicine and Hygiene, 2015)
A 50-year-old male immigrant from Ethiopia presented for consultation after 3 years of hematochezia/melena requiring > 25 units of blood transfusions. Physical examination revealed severe proximal muscle wasting and weakness, ...
Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys
(Associação Brasileira de Divulgação Científica, 2001-12)
Undernutrition elicited by a low-protein diet determines a marked reduction of hypophyseal activity and affects the function of the respective target organs. The objective of the present investigation was to study the ...