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Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
(Pergamon-Elsevier Science Ltd, 2018-03)
Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels ...
Place conditioning with ethanol in rats bred for high (UChB) and low (UChA) voluntary alcohol drinking
(2011)
The main goal of this study was to investigate the ability of an ethanol dose (1. g/kg) administered intraperitoneally to induce conditioned place preference (CPP) and/or conditioned place aversion (CPA) in two lines of ...
Histone deacetylase inhibition decreases preference without affecting aversion for nicotine
(Wiley Blackwell Publishing, Inc, 2011-02)
Epigenetic mechanisms have recently been shown to be involved in the long-term effects of drugs of abuse. A well described epigenetic mechanism modulating transcriptional activity consists in the binding to DNA of methyl-CpG ...
Conditioned Place Preference and Behavioral Analysis to Evaluate Nicotine Reinforcement Properties in Zebrafish
(Springer, 2016)
Studies with mice and rats have demonstrated that nicotine induces a Pavlovian conditioning denominated conditioned place preference (CPP). This behavioral paradigm is performed by exposing an animal to a drug in a particular ...
NMDA antagonist MK 801 in nucleus accumbens core but not shell disrupts the restraint stress-induced reinstatement of extinguished cocaine-conditioned place preference in rats
(Elsevier Science, 2016-12)
Relapse is a common feature of cocaine addiction. In rodents, it can be elicited by cues, stress or the drug. Restraint stress-induced reinstatement of cocaine-conditioned place preference (CPP) is a useful model to study ...
Evaluation of the rewarding properties of nicotine and caffeine by implementation of a five-choice conditioned place preference task in zebrafish
(Pergamon-Elsevier Science Ltd, 2018-06)
The rewarding properties of drugs in zebrafish can be studied using the conditioned place preference (CPP) paradigm. Most devices that have been used for CPP consist of two-half tanks with or without a central chamber. ...
Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents
(Pergamon-Elsevier Science Ltd, 2019-06)
Adolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine ...
Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion
(Wiley, 2012-05)
Adolescent rats exhibit ethanol-induced locomotor activity (LMA), which is considered an index of ethanol's motivational properties likely to predict ethanol self-administration, but few studies have reported or correlated ...
Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference
(Elsevier B.V., 2012-04-04)
It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ...
Effects of combined nicotine and fluoxetine treatment on adult hippocampal neurogenesis and conditioned place preference
(Elsevier, 2015-08)
Adult neurogenesis occurs in mammals within the dentate gyrus, a hippocampal subarea. It is known to be induced by antidepressant treatment and reduced in response to nicotine administration. We checked here whether the ...