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Expression, purification, and circular dichroism analysis of human CDK9
(Elsevier B.V., 2006-06-01)
The human cyclin-dependent kinase 9 (CDK9) protein was expressed in E coli BL21 using the pET23a vector at 30 degrees C. Several milligrams of protein were purified from soluble fraction using ionic exchange and ATP-affinity ...
CDK9 a potential target for drug development
(BENTHAM SCIENCE PUBL LTD, 2008)
The family of Cyclin-Dependent Kinases (CDKs) can be subdivided into two major functional groups based on their roles in cell cycle and/or transcriptional control. CDK9 is the catalytic subunit of positive transcription ...
The Cdk5/p35 complex modulates the activity of the purinergic receptor P2X2
(2017)
We earlier reported that inflammation increases Cdk5 activity, a key protein kinase involved in pain signaling.
Cdk5 sensitizes TRPV1 channel by phosphorylation, causing thermal hyperalgesia. Interestingly, we found ...
Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5 -/- Mice
(2014)
Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells.
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly ...
Estudio molecular del complejo CDK4/Ciclina D/Retinoblastoma
(Universidad de Talca (Chile). Escuela de Ingeniería Civil en Bioinformática., 2022)
Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws
(Pergamon-elsevier Science LtdOxfordInglaterra, 2001)
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
(Wiley & Sons, 2015)
CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment. In a previous study, we ...
A deficitary model of CDK5 does not impairs neuronal differentiation of human pluripotent stem cells
(Medicina, 2021)
CDK5/P35 is a complex involved in neuronal homeostasis and de- velopment that was described as a critical player for neuronal surviv- al. Besides, its deregulation is linked with neurodegenerative pathol- ogies such as ...
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells
(2013)
Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...